Dr Bikman's Lab 1: LEAKY GUT--IS IT REAL? YES

https://www.DoctorsToTrust.com
presents episode 217:

Dr Ben Bikman on
Insulin IQ podcast:
Dr Bikman's Laboratory
August 10, 2021
https://youtu.be/klIDDXaMqDs

Is leaky gut a real health problem?

-it does exist
-where pathogenic molecules move through the wall
of the dirty gut (substances from outside environment)
-role of intestines:
~make sure only substances that
should come into the body do so

-intestines have an exquisitely well-built integrity
-to keep dirty stuff out

-when things begin to break down;
-you have leakage:

"leaky gut"

Is leaky gut a real health problem?

-there is ample peer-reviewed evidence
~using this term
~supporting the reality of it

-usually looking at the migration of a molecule:
-LPS (Lipopolysaccharide)
~found on a bacterium
~moves into bloodstream
~elicits very strong inflammatory
responses

-part of bacteria, that our cells will bind to, including:
~immune cells
~lung cells
~fat cells
~muscle cells

LPS...

-cells will recognize the LPS molecule as part of bacteria,
~will initiate an inflammatory response

cell says:
"I recognize you;
you are a problem; so
I will mount my defenses
to get rid of you"

Normally, in healthy gut, there would be no moving across...

It is not that the LPS is moving throught the gut cells;
-it is moving through the space between the gut cells

When we have the gut cells that line the intestines,
-they are very, very tightly linked together
-by "tight junction proteins"

-they can become lose...
~then have molecules slip through

Liver is the first recipient of these things...

-after they leak through the gut

Blood flows from intestines
-first to the liver
-then to rest of body

The intestines themselves are...
-really on the front line

Intestines have their own very robust set of
-immune cells
~who attempt to mitigate these problems

They become inflammed as they
-try to fight LPS invasion

And what slips through the intestines
-goes directly to the liver

Interesting, because the liver is also...
-site of the solution

When it comes to LPS leaking through the gut into blood,
-what am I eating that makes this happen more readily?

Answer:
-fats
-fructose