DOM D’AGOSTINO 4a | ONCOGENES (cancer causing!)…activated by sugar…killed by fat

http://www.DoctorsToTrust.com
presents episode 464 | Dr Dom D’Agostino
IHMC podcast

Normal mitochondria have cristae (inner and outer membrane)...
-where energy is made
-mitochondria generate ATP (adenosine triphosphate) in cristae
On right: glioblastoma, very aggressive brain tumor has no cristae
-CANNOT GENERATE
ATP
-ketones (fatty acids)
are metabolized
exclusively in
mitochondria
-need mitochondrial
membrane (cristae)
to function

Cancer tumors
HAVE NO CRISTAE

They CANNOT SURVIVE
on ketones for fuel

Mitochondria generate 90% of cell energy...
-with progressive mitochondria dysfunction,
due to chemical & environmental triggers:
~decrease in mitochondrial energy (oxidative phosphorylation)
~INCREASE glucose metabolism energy (substrate level phosphorylation)

Nucleus requires a lot of energy to repair damaged DNA...
-with mitochondrial dysfunction, you have
-impairment of energy production
-TRIGGERS ACTIVATION OF ONCOGENES (cause cancer)
-inhibits tumor-suppressor genes (prevent cancer)

Activation of oncogenes increases the enzymatic activity of glycolysis...
-allows cells to generate energy from sugar
"We have mitochondrial dysfunction that causes genome instability
which activates the cancer genes"

This is what Otto Warburg predicted (Nobel Prize 1931)...
-emerging research from various groups are validating this model

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doctorstotrust.com
ketonutrition.org

Original Youtube: https://youtu.be/gONeCxtyH18
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