Lp-PLA2 Tests for Heart Attack Risk - ELISA Test vs. Activity Assay

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ABOUT THIS VIDEO: A viewer—Patrick Nabors—was confused about the standard limits of the PLAC test. Well, different limits do exist, as there are different kinds of PLAC tests. In this video, I will compare these two types: ELISA test vs. the activity assay.

What is PLAC, by the way? PLAC is an inflammation test (along with MACR, MPO, and HsCRP). It tests for Lp-PLA2, an enzyme that's released by macrophages or foam cells. Lp-PLA2 stands for "lipoprotein-associated phospholipase A2", and it's associated with HDL and LDL particles.

ELISA is the older PLAC test; however, ELISA appears to have problems in measuring the amount linked to lipoproteins and lipopolysaccharides. On the other hand, the newer activity assay appears to have some technical lab advantages as well as stability.
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ABOUT DR. BREWER:
Dr. Brewer started as an Emergency Doctor. After seeing too many preventable heart attacks, he went to Johns Hopkins to learn Preventive Medicine. While there, he went on the run the post-graduate training program (residency) in Preventive Medicine. From there, he made a career of practicing and managing preventive medicine and primary care clinics. His later role in this area was Chief Medical Officer for Premise, which has close to 1,000 primary care/prevention clinics. He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack and stroke prevention clinic.

At PrevMed, we focus on heart attack, stroke, and cognitive decline. We serve patients who have already experienced an event as well as those who have not developed a diagnosis or event. Dr. Brewer provides services via telemedicine or in person if you're in the Lexington, KY area. We find a lot of undiagnosed prediabetes or insulin resistance. Treating unrecognized risk factors like prediabetes allows reduction of risk and prevention of disease.

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