Proteostasis | What is proteostasis | Loss of proteostasis in aging

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Proteostasis | What is proteostasis | Loss of proteostasis in aging
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Proteostasis or protein homeostasis is the process that regulates the maintenance of proteins within the cells. It is a series of mechanisms such as protein synthesis, folding, and degradation that maintains the normal functions of cells. Proteostasis also protects the body against disease and promotes healthy aging. Loss of proteostasis has been considered one of the hallmarks of aging characterized by the accumulation of non native protein aggregates in various tissues. In physiological conditions, proteoastasis network, which is composed of macromolecular machines that maintain proteome integrity, suppresses protein aggregation. As we age, proteostasis network is burdened by the accumulation of damaged and misfolded proteins that have been damaged by stresses, polymorphisms, and translational error, that all lead to modifications such as oxidation. Destabilized proteins with inappropriately exposed hydrophobic regions tend to aggregate with the hydrophobic regions of other proteins forming protein aggregates that can be directly cytotoxic. Pathological protein aggregation is associated with age-related diseases such as Alzheimer's, Parkinson's, frontotemporal dementia, Huntington's disease and amyotrophic lateral sclerosis or ALS.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, LONGEVITY PROTOCOL.

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