MSM

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MSM stands for methylsulfonylmethane. MSM is a naturally occurring organosulfur compound available in a variety of foods, including milk, grains, fruits, and vegetables. It has been used as complementary and alternative medicine. People usually take it for osteoarthritis and other inflammatory disorders such as interstitial cystitis, allergic rhinitis, and acute exercise-induced inflammation. In a study, MSM has been shown to reduce pain and physical function impairment in 50 adults administered with 3 grams of MSM compared to placebo. Moreover, MSM has also produced improvement in performing activities of daily living when compared to placebo, although the underlying mechanisms of action are still yet to be fully understood. In vitro studies suggest that MSM inhibits transcriptional activity of nuclear factor kappa-light-chain-enhancer of activated B cells. The nuclear factor kappa-light-chain pathway is a pro-inflammatory pathway that promotes the production of cytokines, chemokines, and adhesions molecules, which are known to trigger the destruction of the articular joint, leading to osteoarthritis. The downregulation of this pathway induced by MSM also reduces mitochondrial ROS production. MSM is also known to have beneficial and therapeutic effects on skin health because of it is participation in skin physiological processes, including the synthesis of collagen, hyaluronic acid, and keratohyalin. Oral supplementation with MSM has been shown to improve the structural integrity of the skin, which reduces signs of aging like facial wrinkles. Lastly, MSM reduces interleukin 6, which is a pro-inflammatory molecule that exerts stimulatory effects on T and B cells, which in turn favor chronic inflammation involved in the development of chronic diseases associated with aging, including cardiovascular diseases.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, MSM.

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