How to Reverse Biological Age & The Science of Epigenetic Testing | Ryan Smith @ TruDiagnostic

Biological age testing is helping scientists determine the best longevity supplements, drugs, healthy habits, and therapies. If you're looking for the most accurate, repeatable, and effective biological age test, you'll want to use TruDiagnostic.

In this conversation we cover the importance of biological age, the science of epigenetics, powerful lifespan-enhancing technologies, and we walkthrough my personal TruDiagnostic TruAge results.

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📕  Video chapters
0:00 Introduction
1:39 What is epigenetics
2:45 Human Genome Project didn't fully decode us
3:19 Genome, Epigenome, Transcriptome, Proteome, Metabolome, Phenome
5:36 Power of epigenetic clocks
8:03 Chronological age vs biological age
13:40 Buyer's guide to biological age testing products
15:09 What is methylation
15:51 Factors to consider when buying an epigenetic test
21:28 Benefits of biological age testing outside disease prediction
22:27 Algorithms can be trained to predict (and thus improve) virtually any health outcome
24:17 Unlike DNA tests, epigenetics is actionable
28:21 Is methylation good or bad?
34:00 Ryan Smith's top age-reversing protocols
36:23 What are senolytics and why do they matter?
39:06 Natural and easy longevity supplements
40:04 How cellular reprogramming works
42:38 Low supplement bioavailability and absorption may not be bad
47:22 Walking through Nick's personal TruAge biological age test results
54:10 Potential supplements to improve telomere health
64:48 The problems with most epigenetic age testing
69:57 Will TruDiagnostic accept insurance?

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📝 About our guest
Ryan Smith attended Transylvania University and graduated with a degree in Biochemistry. After finishing all the educational curriculum and passing USMLE Step 1 he decided to leave and open up a pharmacy in the United States that focused on peptide synthesis and formulations for pharmaceutical preparations. That pharmacy, Tailor Made Compounding, became the 4th fastest growing company in healthcare in the US. During that time Ryan invested in several businesses in the functional medicine space. Ryan exited Tailor Made in late 2020. Since then, Ryan has opened many businesses including TruDiagnostic, a company focusing on methylation array-based diagnostics for life extension and preventive healthcare.

TruDiagnostic is a CLIA certified lab and health data company focused on serving integrative and functional medicine providers in the United States. TruDiagnostic has a commitment to research with over 30 approved clinical research studies investigating the epigenetic methylation changes of a variety of longevity and health interventions. Since Tru Diagnostic’s inception, they have created one of the largest private epigenetic health databases in the world with over 13,000 patients tested and continue to lead the space in epigenetic methylation interpretation and diagnostic prediction.

🔑 Key takeaways
- Epigenetic algorithms can be used to predict the effect of virtually anything (supplements, sleep, habits, exercise, etc), on any outcome (disease risk, human performance)
- Unlike 23andMe and other DNA tests, epigenetics return actionable and useful results
- When choosing a epigenetic age testing service, research the: sample type, scale of testing, # of CPGs measured, algorithm used, privacy of your data
- Many of the most promising healthspan-increasing modalities are plasma related
- 1 dose of the peptide SS31 is the energy (ATP) equivalent of 6 months of endurance exercise

🔗 Links
- Full episode show notes: https://mindbodypeak.com/47
- Music by Luke Hall: soundcloud.com/c_luke_hall

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Do you have questions, thoughts or feedback? Let me know in the comments below and one of us will get back to you!

Disclaimers:
Nothing posted on this channel is medical advice or a substitute for advice from your physician or healthcare provider. Always contact your healthcare professional with any questions about a medical condition or your personal health. Additionally, some of the links provided above are affiliate links. They don't cost you anything, but I make a tiny commission from the sale. Honesty is key on my channel, and thank you for your support! You may read the full disclaimer here: https://outliyr.com/disclaimers