Autophagy | How cells eat pieces of themselves for survival

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Autophagy is a cellular self-eating process in which intracellular components are catabolized which allows cells to better adapt during periods of stress to avoid death. Autophagy is activated in starved cells to maintain the required ATP production for maintaining energy homeostasis needed to support basic cellular processes. Autophagy is also vital for the maintenance of cellular homeostasis in stem cells that are capable to divide and undergo differentiation to a tissue-specific cell, replenishing old specialized cells. Stem cells also play a pivotal role in preventing the aging process as it maintains normal tissue function. Inducing autophagy in stem cells improves their functions and metabolism. During autophagy, a membrane known as an isolation membrane closes around damaged or old unwanted components in the cytoplasm to form autophagosomes. These components could consist of biological macromolecules like DNA, lipids, proteins, glycogen, organelles like ribosomes and mitochondria, or even entire bacteria. Autophagosomes are then fused with lysosomes to allow the digestion of enclosed components. Autophagy occurs at basal levels, however, basal autophagic activity has been found to decrease with age, compromising the clearance of intracellular residual corpuscles and contributing to the accumulation of dysfunctional organelles and macromolecules during aging. Aging is a biological phenomenon characterized
by a progressive accumulation of damaged organelles and defunct components, which causes the disruption of cellular homeostasis, progressive degeneration, leading to cell death. You can induce autophagy by putting your body in stress conditions like calorie restriction, exercise, or starvation. Starvation is one of the most effective ways to increase autophagic activity. After 24 hours of starvation, autophagy allows cellular processes going by recovering substrates from damaged or unnecessary organelles to be recycled for the synthesis of vital cellular components, helping the body to clear up toxins and infectious agents. It's important to talk to your doctor or other professional before beginning any sort of supplementation or treatments. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, Autophagy.

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