2022 Research: Vitamin D is linked to Slower Epigenetic Aging

A study out of Berlin has shown a clear link between vitamin D levels and the slowing of epigenetic aging using DNA methylation clocks.

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Vitamin D safety Trial: https://www.nature.com/articles/s41430-022-01068-8
Study: https://link.springer.com/article/10.1007/s11357-022-00581-9
https://pubmed.ncbi.nlm.nih.gov/30137208/
https://pubmed.ncbi.nlm.nih.gov/25635171/
https://pubmed.ncbi.nlm.nih.gov/32324874/

The health impact of vitamin D deficiency and benefits of its supplementation are subject to an ongoing controversial discussion. That said, estimations suggest that around 1 billion people worldwide have a serum Vitamin D level below 50 Nanomoles per litre; that number being widely accepted as entry level for vitamin D deficiency. This study’s cohort consisted of participants aged between 60 and 85 involved in the Berlin Aging Study II (BASE-II). The researchers had previously used data from this cohort to determine a relationship between a lack of vitamin D and an accelerated epigenetic age. Their hypothesis was confirmed by the use of 7-CpG, a novel epigenetic clock that is strongly associated with chronological age. That study showed that people who are deficient in Vitamin D have an epigenetic age that is nearly a year older than the average.
This new study however asked a different question: Can restoring Vitamin D levels through supplementation reverse the effects on epigenetic age? To answer this question, this study’s authors utilized over a thousand participants who were approximately 68 years old at baseline and re-examined at an average age of 75.
At baseline, 50% of the participants were deficient in Vitamin D, and of those only 7% were taking supplements.
In the follow-up portion, only 25% were deficient and a fifth (that’s 20%) of the participants were taking supplements.
Both times, about three-fifths (60%) of the participants received their blood draws during the sunnier months of the year, when Vitamin D deficiency, in theory, is less likely. They noted that, some people who were originally taking Vitamin D supplements had stopped - and 82% of the supplement takers in this study had only begun supplementation after their baseline examination. In order to analyze the effects of Vitamin D supplementation, the researchers identified 63 people who had previously been deficient in Vitamin D, but had become sufficient after supplementation; they were named the “treated group.” They then matched these participants (based on demographic data) to 63 people who were deficient and un-supplemented, marking them as the “untreated group.” After matching the treated and untreated group, another 63 un-supplemented but healthy people were used as the “control group.”
The results were clear in only two of the five epigenetic clocks used. Participants who went from deficient to sufficient through vitamin D supplementation were shown to be epigenetically younger by more than two and a half years according to the 7-CpG clock.
And 15 months younger according to the Horvath epigenetic clock, which is also used to measure chronological age. However, while some effects were visible on the Hannum, GrimAge, and Levine clocks, these differences were not deemed to be statistically significant.
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