5 More Supplements for Schizophrenia

List of constantly updated tips:
https://schizoprevent.blogspot.com/2021/03/strategies-for-improving-schizophrenia.html

1)Brain Directed Multivitamin (EMPowerPlus)
Creates energy
Helps with pyroluria (Zinc, B6, Manganese, Vitamin C, and Magnesium help this and 50% of schizophrenics may have it)
Cures bipolar (in many studies), helps schizophrenics in one study (7 patients)
People are not getting enough nutrients in their diet
Naturopaths often recommend this
TrueHope offers a 45% discount for those on disability
They make supplement councillors available to adjust dosages
This helped me sleep less and be more active

2)Yokukansan (aka Yi Gan San) doesn't help in one (double blind placebo controlled) but does help in others: 25% improvement positive symptoms, 45% in negative and general symptoms in the PANSS test, severity of schizophrenia down by 60%, stops tardive dyskinesia (87% average reduction).
2.5g powder 3 times a day before meals (7.5g total) or 1.5g extract 3 times a day duration 12 weeks
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411464/
Google drive
No adverse reaction reported
Doesn't interact negatively with antipsychotic
Haven't researched supplement interactions with other recommended supplements yet.

3)Lion’s Mane Mushroom
Encourages nerve growth, helps fatigue, builds myelin sheaths, protects against neuron death from oxidative or endoplasmic stress (antioxidant activity is however 4x lower than vit C and can be combined with other antioxidants)
25 to 30% improvement to positive negative and cognitive symptoms (though some is placebo, and it was tested in refractory schizophrenics only)
Slows glucose absorption in the gut
27% lower triglyceride levels and 42% less weight gain after 28 days (in mice)
1000mg to 3000mg (2000mg average dose) Amyloban 3399 was used
Other brands work fine, but strengths can be different. I suggest you follow the recommended dosing from your provider
2 studies (small trials (case studies only))
Some of the benefit of Lion's Mane might be similar to the KETO/carnivore diet due to lower triglycerides and lower blood glucose
https://www.healthline.com/nutrition/lions-mane-mushroom#TOC_TITLE_HDR_9
Those who experienced the greatest improvement in cognition, mood, and sense of well-being were not on any prescription medication such as statins, hypertensive drugs, or blood thinners. Overall, the results of the study showed that Amyloban3399 improved mood, memory, and sense of well-being in 100% of those who were free of any medication.
(Google drive link)
Effect size is not retained (continuous treatment necessary (for above cognition study at least)
Side Effects:
testing in rats @ high doses with no ill effects
Possible allergic reaction to the mushroom in some humans
Lions Mane has long been consumed as food in Asia
Precaution:
Lowers blood sugar
Lowers blood clotting (careful when having surgery, or if prone to bleeding (though no reports of this happening in humans)
blood test (for schizo diagnosis) (seems fairly accurate in young people only, High CRMP2 also causes dendrites to be smaller, potentially fixed by Lion's Mane)

4)Betaine
Makes neurons look less sick (healthier non-hyperbranching) in mice
Zinc and B6 also help with this
2 studies in mice, 1 friend who it helped
Thought you should use trimethylglycine (betaine anhydrous) but my friend recommended betaine hydrochloride(?)
Stops working when discontinued
Toru Mizoguchi uses Betaine (Famous Japanese Ortho Psychiatrist)

5)CoQ10
Many people believe energy systems in the body are effected by schizophrenia. Including the main source of cell energy the mitochondria. Therefore taking some supplements for energy may provide a large benefit.
I'd recommend magnesium, b vitamins including b12, CoQ10, NAD boosters such as nicotinamide riboside (NR) acetyl l carnitine, french oak extract, two people had benefit from alpha lipoic acid (strong antioxidant so perhaps don't mix with cod liver oil), PQQ has be known to provide energy benefits also (though it is a strong antioxidant so perhaps don't take cod liver oil and PQQ at the same time (switch to regular fish oil for a period) (acts similar in some ways as lions mane), exercise also helps energy (see above), fisetin, brahmi,
https://www.lifeextension.com/magazine/2020/10/constantly-tired-oak-wood-fights-fatigue?
https://wholefoodsmagazine.com/columns/vitamin-connection/increased-energy-and-performance-as-well-as-detoxification-with-bioflavonoids-from-robuvit-french-oak-extract/

0:00 Intro
0:23 EMP+
4:31 Yi Gan San
7:19 Lion's Mane Mushroom
10:26 Betaine
13:35 CoQ10
15:03 Summery