Metronidazole(Flagyl) - Mechanism Of Action, Indications, Adverse Effects & Contraindications

Metronidazole, commonly known as flagyl, is a 5 nitro imidazole that targets the DNA synthesis in bacteria and other organisms, such as protozoans. When administered, metronidazole is reduced to form its highly reactive nitro free radical by the enzyme ferredoxin. This leads DNA damage and fragmentation, and ultimately, death of the organisms.

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