Long Story Short Episode 38: Nattokinase Antithrombotic Mechanism of Action

Nattokinase Part 1 of 3 (to be followed by Part 2: Nattokinase and The Degradation of the Spike Protein and Part 3: Nattokinase: Dosing and Safety)

Nattokinase is a thrombolytic, spike protein degradative, and anti-aging enzyme produced by Bacillus subtilis. Nattokinase is made by fermenting soybeans with Bacillus subtilis. Let's review its actions.

URL list from Monday, Dec. 19 2022

File:Natto mixed by Kinchan1.jpg - Wikimedia Commons
https://commons.wikimedia.org/wiki/File:Natto_mixed_by_Kinchan1.jpg

Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372539/#:~:text=Mechanism%20of%20Action.,activator%20(t%2DPA)

Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2 - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458005/

A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles | Scientific Reports
https://www.nature.com/articles/srep11601

Mechanism of Action. Nattokinase dissolves blood clots by directly... | Download Scientific Diagram
https://www.researchgate.net/figure/Fig-2-Mechanism-of-Action-Nattokinase-dissolves-blood-clots-by-directly-hydrolyzing_fig2_321687198

Coagulation and fibrinolytic cascades. Ca, calcium; FDPs, fibrin... | Download Scientific Diagram
https://www.researchgate.net/figure/Coagulation-and-fibrinolytic-cascades-Ca-calcium-FDPs-fibrin-degradation-product_fig2_284136686

Coagulation and anticoagulation in idiopathic pulmonary fibrosis | European Respiratory Society
https://err.ersjournals.com/content/24/137/392.figures-only

Coagulation Clotting Mechanisms - Circulatory System - MCAT Content
https://jackwestin.com/resources/mcat-content/circulatory-system/coagulation-clotting-mechanisms

Physiology, Coagulation Pathways - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK482253/#:~:text=The%20intrinsic%20pathway%20is%20activated,endothelial%20cells%20after%20external%20damage.&text=This%20pathway%20is%20the%20longer%20pathway%20of%20secondary%20hemostasis.

Intrinsic Pathway of Coagulation and Thrombosis | Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.118.312130

Plasmin - Wikipedia
https://en.wikipedia.org/wiki/Plasmin

Urokinase - Wikipedia
https://en.wikipedia.org/wiki/Urokinase

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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