Literature Review: Ovarian and Uterine Effect of Testosterone on FTMs

https://sci-hub.ru/https://pubmed.ncbi.nlm.nih.gov/27751416/
Literature Review is the playlist where I read and comment on peer-reviewed articles related to the trans topic that I consider to be good science. For articles I consider to be propaganda, see the playlist Glitterature Review on exulansic.com.

Highlights from this paper: testosterone induced a high rate of uterine fibroids and fibrous collagen tissue in ovaries which became, in view of the authors, functionally equivalent to polycystic ovaries. The authors found evidence the endometrial tissue was doing something it only is known to do when cancerous: aromatize testosterone to estrogen.

Finally I comment on my hypothesis that there exists at least one woman in the world of billions who has an unacknowledged form of CAIS. She has 46XX chromosomes, ovaries, fallopian tubes, uterus, and vagina. Due to androgen insensitivity, she struggles with female infertility, in combination with other symptoms such as reduced body hair and body odor. This is a distinct form of CAIS than would occur in a patient with 46XY chromosomes and testicles.

Contrary to the prevailing narrative that CAIS, a genetic disorder of the X chromosome, can only exist in XY people, I propose that a homozygous XX form of CAIS is clearly possible via de novo mutations from a fertile father who did not himself have CAIS but still produced a sperm with a broken androgen receptor gene on an X chromosome which combined with a maternal egg which also had a broken androgen receptor gene. 1/3 of known forms of XY CAIS (300 of 900 described variants) arise from de novo mutations. She's out there and no one is considering that this might be the reason she can't get pregnant.
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