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表观遗传变化是哺乳类动物衰老的主要驱动因素
2 years ago
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https://t.me/fanmiaojidi/5233
《哈佛医学院》一项为期13年的小鼠国际研究表明,影响DNA组织和调节方式的丢失和退化(称为表观遗传学)可以驱动生物体衰老,与遗传密码本身的变化无关。
这项研究表明,表观遗传信息的崩溃能导致小鼠衰老,而“恢复表观基因组的完整性”可以逆转这些衰老迹象。
研究表明:表观遗传变化是哺乳类动物衰老的主要驱动因素。
研究团队广泛的一系列实验提供了确据:“DNA变化不是唯一的元素,甚至不是主要的衰老原因。相反,研究结果表明,染色质(形成染色体的DNA和蛋白质的复合物)的化学和结构变化会在不改变遗传密码本身的情况下加速衰老。”….
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