TURN ON 3 GENES: Dr. David Sinclair

OCT4, SOX2, and KLF4 are transcription factors that play essential roles in cellular pluripotency, reprogramming, and development. They are commonly referred to as part of the Yamanaka factors, which also include c-Myc. These factors were identified by Dr. Shinya Yamanaka, who found that introducing them into adult somatic cells could reprogram these cells into induced pluripotent stem cells (iPSCs), which have the potential to differentiate into various cell types. Here's a brief description of each gene:

OCT4 (Octamer-binding transcription factor 4): Also known as POU5F1, OCT4 is a key transcription factor required for maintaining the pluripotency and self-renewal of embryonic stem cells. It regulates the expression of several genes involved in early embryonic development and cell fate decisions. The OCT4 protein contains a POU (Pit-Oct-Unc) domain, which is essential for DNA binding and transcriptional regulation.

SOX2 (SRY-box transcription factor 2): SOX2 is another critical transcription factor involved in maintaining the pluripotency of embryonic stem cells. It is a member of the SOX (SRY-related HMG-box) family of transcription factors, which share a highly conserved HMG (high-mobility group) DNA-binding domain. SOX2 is crucial for the early stages of embryonic development and works in concert with OCT4 to regulate the expression of genes that maintain pluripotency and inhibit differentiation.

KLF4 (Krüppel-like factor 4): KLF4 is a zinc-finger transcription factor that plays a significant role in various cellular processes, such as cell proliferation, differentiation, and apoptosis. In the context of pluripotency, KLF4 works together with OCT4, SOX2, and c-Myc to reprogram somatic cells into iPSCs. KLF4 is also involved in the regulation of genes associated with cell cycle progression and differentiation.

Together, OCT4, SOX2, and KLF4 (along with c-Myc) play pivotal roles in cellular reprogramming and the maintenance of pluripotency in stem cells, contributing to the fields of regenerative medicine and developmental biology.

Dr. David Sinclair is a prominent Australian biologist and Harvard Medical School professor, known for his pioneering research in aging and lifespan extension. His work focuses on understanding the role of genes and molecules that regulate aging, particularly sirtuins and nicotinamide adenine dinucleotide (NAD+). Sinclair has co-founded biotechnology companies to develop anti-aging therapeutics and is an influential science communicator. He is the author of the bestselling book "Lifespan: Why We Age – and Why We Don't Have To," which explores the current understanding of aging and the potential future of anti-aging therapies.

Resources for the Supplements Discussed in This Video

Alpha-Ketoglutaric Acid (AKG) is a dietary supplement involved in the Krebs cycle, which is crucial for cellular energy production. AKG plays a role in energy production, amino acid metabolism, nitrogen balance, detoxification, and antioxidant support. Some research also suggests potential anti-aging benefits. It's important to consult a healthcare professional before starting any new supplement to ensure it's appropriate for your needs and minimize any risks.
AKG Supplement (Alpha Ketoglutaric Acid) - https://amzn.to/41oqq1y

Additional beneficial supplements that contribute to combating the aging process

GENEX Berberine HCl 500mg - https://amzn.to/3UxmR6Z
Mitochondria Maximizer with CoQ10 and Active PQQ - https://amzn.to/43ufH7z
Nutricost Alpha Lipoic Acid 600mg Per Serving - https://amzn.to/3o3sWf8
Nutricost L-Carnitine Tartrate 1,000mg - https://amzn.to/3zVa4BE
Super Greens Powder Premium Superfood - https://amzn.to/418DxUL
ZEBORA Probiotics Digestive and Immune Gut Health - https://amzn.to/3UEpQuy
AKG Supplement (Alpha Ketoglutaric Acid) - https://amzn.to/3MGtVMy
Multivitamin Powder - https://amzn.to/416pCyI
Genex NAD+ 250mg Serving 60 Capsules - https://amzn.to/3KWFE8E
GENEX 99% Micronized Trans-Resveratrol Powder - https://amzn.to/401RbI0
Multi Collagen Powder - https://amzn.to/43INTfY
Organic Vitamin D3 K2 Drops w MCT Oil - https://amzn.to/3KWdCdo

#AKGsupplement #AlphaKetoglutaricAcid #KrebsCycle #CellularEnergy #ATPproduction #AminoAcidMetabolism #NitrogenBalance #Detoxification #AntioxidantSupport #AntiAgingBenefits #MitochondrialFunction #EnergyBoost #MetabolicHealth #AmmoniaScavenger #ProteinSynthesis #DietarySupplement #Supplements #HealthAndWellness #Nutrition #HealthyAging #Biochemistry #CellularProcesses #LiverHealth #OxidativeStress #InflammationReduction #EnergySupplement #CellularHealth #AmmoniaDetox #ConsultAProfessional #SupplementSafety