2 years ago

Dose-response meta-study...
For those with prostate cancer
-higher levels of vitamin D
= lower mortality
"This is along with standard
prostate cancer treatments"
-everyone with prostate cancer
should titrate vitamin D up
-vitamin D doses are cheap
-large scale trials not being done

Results
"Higher vitamin D could reduce
risk of death for prostate
cancer"
-measured 25 OHD--activated
vitamin D in blood
-7 studies: [7800 patients]
-each 20 nmol/L [8 ng/mL]
increase vit D
=9% DECREASE IN DEATH
-significant at p=0.002
HR .91 [91% risk vs non-vit D]

This was all-cause mortality
& prostate cancer-specific
mortality
"For each 20 [8] increase in D
9% less likely to die.
If 40 [16], then 18% less likely"

Upper and lower lines were
levels of vitamin D
Middle lines were combined
from all studies using 2
different mathematical
calculation models

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@campbellteaching

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