"mRNA technology is a good fit for gene editing. We want to make these editing proteins for just a short period of time to modify the genome. And producing the editing enzymes transiently helps to reduce the potential for off-target effects."

"mRNA technology is a good fit for gene editing. We want to make these editing proteins for just a short period of time to modify the genome. And producing the editing enzymes transiently helps to reduce the potential for off-target effects."
Closing quote
Seng Cheng, Vice President and Chief Scientific Officer of the Rare Disease Research Unit at Pfizer.
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Unlocking the Power of Our Body's Protein Factory - mRNA Part 2 | Pfizer
https://www.pfizer.com/news/behind-the-science/unlocking-power-our-bodys-protein-factory
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Intracellular Delivery of mRNA for Cell-Selective CRISPR/Cas9 Genome Editing using Lipid Nanoparticles
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200801
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Jenifer Dudna (2015) CRISPR CAS9 Uses (TED TALK) https://youtu.be/TdBAHexVYzc
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Biotechnology: Genetically Engineered Pathogens (The Counterproliferation Papers, Future Warfare Series No. 53) USAF COUNTERPROLIFERATION CENTER MAXWELL AFB AL (US BIOWARFARE MANIFESTO ?!)
https://apps.dtic.mil/sti/citations/ADA556597
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PFIZER: WHAT IS mRNA? - To enter cells smoothly, mRNA travels within a protective bubble called a Lipid Nanoparticle. Once inside, our cells read the mRNA as a set of instructions, building proteins.
https://www.pfizer.com/science/innovation/mrna-technology
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Our cells are prolific protein factories.
And mRNA plays a key role in this process.
Messenger RNA is a molecule found in every living being. If DNA is our instruction manual for life, then mRNA is a single-page photocopy from this book—carrying genetic information for a specific protein.

Turning your body
into medicine factories
Scientists are looking to apply mRNA across a broad range of diseases. What makes it so versatile? The answer comes down to two basic biological principles:
Using these mRNA instructions, our cells make the proteins we need to sustain life.
https://www.pfizer.com/news/behind-the-science/how-once-little-known-molecule-disrupting-medicine
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Unlocking the Power of
Our Body’s Protein Factory
By Sachi Fujimori | June 2022
"mRNA technology is a good fit for gene editing. We want to make these editing proteins for just a short period of time to modify the genome. And producing the editing enzymes transiently helps to reduce the potential for off-target effects." https://www.pfizer.com/news/behind-the-science/unlocking-power-our-bodys-protein-factory
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The optimal delivery of mRNA by using lipid nanoparticles (LNPs) can be achieved through a rational design process and high-throughput screening of a lipid library. The spatiotemporally controlled delivery of mRNA-encoding CRISPR/Cas9 can provide an effective and convenient approach for cell-selective genome editing and targeted gene therapy.
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200801
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The technology was developed from a natural defence system that pastes a virus's genetic material next to CRISPR sequences in a bacterium's genome, enabling the cell to remember the invader.
Proteins, known as Cas enzymes, use a CRISPR sequence like a Wanted Poster. They recognise and cut up the virus if it tries to reinfect.
https://www.google.com/amp/s/www.sciencefocus.com/the-human-body/rna-in-crispr-and-mrna-vaccines/amp/
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