2 years ago

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In his latest study David Sinclair has successfully reversed the age of human cells, using chemicals and not genetics.
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Links:
https://www.aging-us.com/article/204896/text
https://pubmed.ncbi.nlm.nih.gov/37437248/
https://phys.org/news/2023-07-discovery-chemical-reverse-aging-cellular.html
https://en.wikipedia.org/wiki/Induced_pluripotent_stem_cell
https://rb.gy/k54wz
https://rb.gy/yx06u

A team led by famed, some may say infamous, Harvard Medical School anti-aging researcher Dr. David Sinclair have just published a paper, that shows that a specific mix of chemicals are capable of reversing cellular aging. If it sounds too good to be true, it could well be. So far, the evidence is only in human cells in the lab, it appears that we are a long way from testing this on animal models, and obviously further away from human trials.
Dr. David Sinclair PhD, a professor in the Department of Genetics at Harvard Medical School wrote in the paper "We identify six chemical cocktails, which, in less than a week and without compromising cellular identity, restore a youthful genome-wide transcript profile and reverse transcriptomic age. Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means."
If this statement is taken out of a cell-level context, which some individuals appear to have done for some reason, this amounts to a very bold claim, given how early in the process this research is. So, it's unsurprising that there's already some controversy surrounding this paper.
The study looked at the way our cells lose information as they age, specifically their epigenetic information. As they get older, our cells go from having unlimited potential when we're embryos, to separating into just one specific cell type, and eventually becoming senescent, running out of functionality, and dying.
In 2012, Shinya Yamanaka and Sir John Gurdon won a Nobel Prize for showing this process can actually be reversed. They found that turning on the so-called Yamanaka factors (OCT4, SOX2, and KLF4) in mammals can turn adult cells back into induced pluri-potent stem cells with unlimited potential. A few years later, a team of researchers showed that even temporarily turning on these Yamanaka factors in mice made the rodents healthier.
Since then, the race has been on to apply the same idea in humans, but without turning cells cancerous, which is a real risk when you give cells the ability to divide endlessly. Doctor Sinclair's lab has already achieved promising early results, they have been able to use Yamanka factors to restore vision in mice and monkeys who had damaged optic nerves.
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