How did Ivermectin get caught up in COVID-19?

Aug 01, 2023
Source: https://philipmcmillan.substack.com/p/how-did-ivermectin-get-caught-up

Ivermectin was discovered in the late 1970’s and hailed as a remarkable drug because of the impact of reducing diseases for hundreds of millions in the developing world.

There are few drugs that can seriously lay claim to the title of ‘Wonder drug’, penicillin and aspirin being two that have perhaps had greatest beneficial impact on the health and wellbeing of Mankind. But ivermectin can also be considered alongside those worthy contenders, based on its versatility, safety and the beneficial impact that it has had, and continues to have, worldwide—especially on hundreds of millions of the world’s poorest people.

Crump, Andy, and Satoshi Omura. "Ivermectin,‘wonder drug’from Japan: the human use perspective." Proceedings of the Japan academy, Series B 87.2 (2011): 13-28.

Ivermectin was initially not a major focus of my research, as it was unclear the mechanism of action based around my autoimmune perspective. However, the mode of action stood out at the time as being immune modulatory.

“In this review, Rick Maizels and Rachel Lawrence argue that microfilariae and adult parasites induce a form of immunological tolerance which prevents both parasite elimination and progression to disease. The breakdown of this unresponsiveness is seen as the critical step towards pathogenesis.”