What Syphilis Does to the Body | And Should You Get Tested?

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What Syphilis Does to the Body | And Should You Get Tested?

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In this video, Jonathan from the Institute of Human Anatomy discusses what causes syphilis, the problems it causes throughout the body, how it is treated, as well as who should consider getting tested.

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Video Timeline

00:00 - 00:34 Intro
00:35 - 01:17 How You Get Syphilis
01:18 - 01:57 What is the First Sign of Syphilis?
01:58 - 03:17 When & Why Syphilis is So Contagious
03:18 - 04:22 The Rash & Next Stage of Syphilis
04:23 - 04:59 Syphilis Can Stay Dormant For Years!
05:00 - 06:25 The Damage Untreated Tertiary Syphilis Can Cause
06:26 - 07:36 Is There a Cure For Syphilis?
07:37 - 08:49 Is There Any Permanent Damage From Syphilis?
08:50 - 10:20 Who Should Get Tested For Syphilis?
10:21 - 12:02 Becoming More Brilliant!

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Treatment Protocols:

Primary, Secondary, & Early Latent Syphilis
-Preferred: Penicillin G benzathine 2.4 million units IM once
-Alternatives (choose one):Doxycycline 100 mg orally twice daily for 14 days, or Ceftriaxone 1 g daily IM or IV for 10 to 14 days

Tertiary & Latent Latent Syphilis (no neurologic symptoms)
-Preferred: Penicillin G benzathine 2.4 million units IM once weekly for three weeks
-Alternatives (choose one): Doxycycline 100 mg orally twice daily for four weeks, or Ceftriaxone 2 g daily IM or IV for 10 to 14 days

Neurosyphilis (early or late, can occur at anytime during course of infection)
-Preferred: Aqueous penicillin G 3 to 4 million units IV every four hours (or 18 to 24 million units continuous IV infusion) for 10 to 14 days. If possible, patients allergic to penicillin should be desensitized and treated with IV penicillin
Alternatives (choose one): Penicillin G procaine 2.4 million units IM daily plus probenecid 500 mg orally four times daily, both for 10 to 14 days, or Ceftriaxone 2 g IV daily for 10 to 14 days

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References:
Syphilis: Treating & Monitoring
https://www.uptodate.com/contents/syphilis-treatment-and-monitoring?search=syphilis&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2#H2782145010

Syphilis: Epidemiology, pathophysiology, and clinical manifestations in patients without HIV
https://www.uptodate.com/contents/search?search=syphilis&sp=0&searchType=PLAIN_TEXT&source=USER_INPUT&searchControl=TOP_PULLDOWN&searchOffset=1&autoComplete=false&language=en&max=10&index=&autoCompleteTerm=

Syphilis – CDC Basic Fact Sheet
https://www.cdc.gov/std/syphilis/stdfact-syphilis.htm#:~:text=Syphilis%20is%20a%20sexually%20transmitted,have%20different%20signs%20and%20symptoms.

Sexually Transmitted Disease Surveillance 2021
https://www.cdc.gov/std/statistics/2021/default.htm#:~:text=Reported%20cases%20of%20syphilis%20(all,in%20the%20past%20five%20years.

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Picture Attributions:
CDC/M. Rein, VD, Public domain, via Wikimedia Commons
https://commons.wikimedia.org/wiki/File:Chancres_on_the_penile_shaft_due_to_a_primary_syphilitic_infection_caused_by_Treponema_pallidum_6803_lores.jpg

The original uploader was Pygmalion at German Wikipedia., CC BY-SA 3.0
The original uploader was Pygmalion at German Wikipedia., CC BY-SA 3.0 http://creativecommons.org/licenses/by-sa/3.0/, via Wikimedia Commons

CDC/ J. Pledger, Public domain, via Wikimedia Commons
https://commons.wikimedia.org/wiki/File:Gumma_of_nose_due_to_a_long_standing_tertiary_syphilitic_Treponema_pallidum_infection_5330_lores.jpg

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#anatomy #syphilis #std