Long Story Short Episode 65: Adaptogenic Effects of Ashwagandha

The third in a series about the beneficial effects of Ashwagandha, this episode looks at the anti-stress and adaptogenic effects of this incredible herb. Ashwagandha helps improve neuronal plasticity and regeneration, and reduces the damage and death of these cells. To accomplish this effect, ashwagandha triggers the upregulation of HSP70 proteins. Let's review.

URL list from August 3, 2023

Pharmaceutics | Free Full-Text | Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
https://www.mdpi.com/1999-4923/15/4/1057

Evidence-Based Efficacy of Adaptogens in Fatigue, and Molecular M...: Ingenta Connect
https://www.ingentaconnect.com/content/ben/ccp/2009/00000004/00000003/art00004

Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895966/#:~:text=Heat%20shock%20protein%2070%20(Hsp70)%20is%20a%20molecular%20chaperone%20that,or%20aggregation%20until%20conditions%20improve.

Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0091305703001102

Phytotherapy Research | Medicinal Chemistry Journal | Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.858

Frontiers | c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease
https://www.frontiersin.org/articles/10.3389/fphar.2015.00321/full

Frontiers | DAF-16/FOXO Transcription Factor in Aging and Longevity
https://www.frontiersin.org/articles/10.3389/fphar.2017.00548/full

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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