NADIR ALI d’ | CHOLESTEROL so important to BRAIN…it makes its own

http://www.DoctorsToTrust.com
presents episode 1077 | Dr Nadir Ali
Nadir Ali MD podcast

Szczepaniak 2009 showed that those with T2D or obese or
insulin resistant: stepwise increase in pancreas fat...
-liver spews out lots of sugar
-insulin UP but
-no phase 1 response
-glucagon cells covered in fat
-so GLUCAGON way UP
-CYCLE CONTINUES AS
DOCTORS SAY: EAT CARBS!

On left: normal response
Right: abnormal
-no insulin spike
-no suppression of glucagon
-glucose way UP

Cholesterol critical for brain...
Brain makes OWN CHOLESTEROL
-transported in brain: ApoE
-ApoE: protein lipidated by
astrocytes
-takes cholesterol to different
parts of the neuron

Types of ApoE: 4, 3, 2 one from each parent...
4: from hunter-gatherer natives
-most susceptible to cleavage
3: European
2: Agricultural; Asian; Greek
SYNAPTIC CONNECTION BETWEEN
BRAIN CELLS NEED CHOLESTEROL
-aided by cholesterol-rich areas
-receptors sit in cholesterol-rich
lipid rafts

ApoE is so important in supplying cholesterol, needed for
-neuron growth
-microtubule stability
-clear AMYLOID
-synaptic plasticity
-SURVIVAL

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@eatmostlyfat

Original Youtube: https://youtu.be/ELxqG-VNvUY?si=1MTKfzvkqGrdGX1L
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