NADIR ALI b’ | Injected insulin can't match natural insulin: glucagon response: bad glucose control

http://www.DoctorsToTrust.com
presents episode 1075 | Dr Nadir Ali
Nadir Ali MD podcast

Pancreas: red cells are insulin-producing beta cells...
-green produce glucagon
Type 1 diabetics have no
beta cells
Type 2 diabetics have
hypertrophied beta cells
[ineffective]
Both alpha & beta cells
close to each other...
Dr Unger asked: is this
for a purpose?

Paracrine signaling: means local control
[endocrine means signal comes from pancreas]
-insulin created in pancreas
to have effect on brain
Insulin begins in beta cells
-highest concentration at
alpha cells making
glucagon
"Role of insulin is to SHUT
DOWN GLUCAGON"
[from Dr Roger Unger]

From Dr Roger Unger:
When insulin reaches liver, it is diluted 10x...
-when enters circulation:
diluted 100x
Injected insulin can
NEVER DUPLICATE THIS
[liver will never see this
normal concentration of
insulin]

From Dr Roger Unger:
As there are slight fluctuations in sugar
-beta cells release insulin
in phase 1 response
-in a squirt to suppress
glucagon
Continues to suppress
glucagon thru phase 2

When not eating, glucagon levels are high...
Tells liver: put out sugar
-burn muscles, convert to
sugar
-take glycerol from fat &
convert to sugar
-take fatty acids &
convert to KETONES

Paracrine action between alpha and beta cells when eating...
-insulin tells :
-use & store sugar
-build new protein
-store fat
When NOT EATING
glucagon tells:
-release sugar from liver
-break down protein to
make sugar
-release fat for sugar & ketones

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@eatmostlyfat

Original Youtube: https://youtu.be/ELxqG-VNvUY?si=1MTKfzvkqGrdGX1L
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