NADIR ALI d” | Older & sedentary? high risk of fat toxicity & sarcopenia

http://www.DoctorsToTrust.com
presents episode 1089 | Dr Nadir Ali
Low Carb Denver podcast

Age associated w/ mitochondrial dysfunction, IR & lipotoxicity...
Study: younger 20s & older 70s
-similar in weight, fat mass, lean mass, BMI
-Kraft test showed:
Older:
-higher glucose & insulin
-higher muscle & liver fat
-40% lower ATP power

Statins: lack of data, but inferential information shows...
Statins
-cause IR
-poisons mitochondria by depleting Coq10
-increases liver's & pancreas'
VLDL receptors so they
become fatty & toxic

Damaged mitochondria [yellow] bond with healthy in
complementation: to prevent forming free radicals...
Or, mitochondria can separate damaged part into:
-daughter: damaged
-daughter: healthy
Damaged daughter
cleared from cell by
mitophagy

In setting of exercise, healthy mitochondria: ATP used as fuel...
-AMP goes up, giving strong signal to cell to produce
mitochondrial biogenesis factor[PCG-1alpha]
Initiates
-mitophagy
-fusion, fission
-biogenesis

In setting of sedentary behavior, lipotoxicity, IR...
-creating lots of toxic fat damaging mitochondria
-won't burn freely
-generate lots of free radicals [causing aging]
-toxic fat [ceramide]
-forms channel leaking
out critical proteins
-program cell for death
-leading to sarcopenia

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Original Youtube: https://youtu.be/4-fQJAifTg0?si=w0wgsIPqM8zxxchu
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