2 years ago

In this video, Dr Sanjeev Goel and Omiya Goel discuss the neurobiology of sleep and the new medication called Lemborexant (Dayvigo), and its mechanism of action.
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Do you struggle with insomnia? Are you curious about the latest developments in sleep medicine? In this video, Dr. Sanjeev Goel and Omiya Goel take a deep dive into the neurobiology of sleep and explore a promising new medication called Lemborexant (Dayvigo).

You'll learn about the different stages of sleep, how they affect our bodies and brains, and what happens when we don't get enough quality sleep. Dr. Goel and Omiya will also explain how Lemborexant works in the brain to promote better sleep and discuss its potential benefits and side effects.

Whether you're a medical professional, someone who struggles with sleep issues, or just curious about the latest research on sleep medicine, this video is for you. Join us as we explore the fascinating world of sleep and the exciting new developments in insomnia treatment.

Here is an excellent review article on the physiology of sleep
https://journals.physiology.org/doi/full/10.1152/physiol.00013.2018

Information on Dayvigo - Lemborexant
https://www.dayvigo.com/

TIMESTAMP
0:00 - Introduction
0:31 - Importance of sleep and its function
1:01 - Characteristics of sleep (REM and non-REM sleep)
1:53 - External and internal cues that help with sleep
3:00 - Process S (gradual build-up of molecules that make you sleepy)
4:06 - Process C (circadian clock)
5:02 - Peripheral clocks
7:56 - Graph showing the interaction between Process S and Process C
9:19 - Sleeping pills that stimulate GABAergic neurons
10:24 - Introduction to a new class of medication called an orexin antagonist