Premium Only Content
How Do Erectile Dysfunction Drugs Work? A Complete Rundown on PDE5 Inhibitors
If you’ve searched online for information about treating ED, you’ve likely heard of medications called PDE5 inhibitors.
PDE5 inhibitors are medications that improve blood flow to certain tissues, including the tissue of the penis. They work by inhibiting the action of phosphodiesterase-5, an enzyme that can be found in the smooth muscle cells of blood vessels.
Although PDE5 inhibitors were originally designed to treat cardiovascular health issues, they’re most commonly used today to treat erectile dysfunction.
Common PDE5 inhibitors available today include Viagra® (which contains the active ingredient sildenafil), Cialis® (tadalafil), Levitra® (vardenafil) and Stendra® (avanafil).
Below, we’ve explained what PDE5 inhibitors are, how they work and how you might be able to use them to treat ED.
We’ve also discussed several important topics related to PDE5 inhibitors, from side effects and interactions to frequently asked questions and more.
-
5:04:59
Drew Hernandez
1 day agoERIKA KIRK FINALLY CLAPS BACK: CANDACE OWENS RESPONDS
39.4K41 -
35:33
Stephen Gardner
11 hours agoThe Supreme Court Just Changed History FOREVER!
117K87 -
14:14
Robbi On The Record
13 days ago $11.69 earnedThe Identity Crisis No One Wants to Admit | Identity VS. Personality
65.9K14 -
2:17:43
ThatStarWarsGirl
6 hours agoTSWG LIVE: Supergirl Is COMING!
40.7K2 -
28:03
Welker Farms
10 hours ago $2.06 earnedNo Stopping The International Harvester 9370! ...except for that fuel leak...
31.1K1 -
14:58
Upper Echelon Gamers
6 hours ago $4.37 earnedTotal Stagnation - The AI "Nothing" Products
32.8K5 -
1:12:09
MattMorseTV
8 hours ago $48.97 earned🔴Trump just GUTTED the ENTIRE SYSTEM. 🔴
74.7K118 -
1:35:14
Badlands Media
1 day agoAltered State S4 Ep. 7 – The MAHA Wins, RFK’s Enemies & the Medical Deep State Exposed
54.8K10 -
14:37
World2Briggs
12 hours ago $3.18 earnedTop 10 States Americans Regret Moving To
21.6K12 -
1:07:59
TheCrucible
10 hours agoThe Extravaganza! EP: 73 (12/10/25)
264K49