Ep 9: Dave Feldman, Citizen Scientist—What Causes Heart Disease

Dave Feldman and I discuss the what causes heart disease, specifically focusing on the consensus view and how it differs from what the science actually shows.

Topics:
Basic theory of CVD causation:

• High ApoB/LDL/Cholesterol
• Gradient causes penetration of arterial wall
• Cholesterol/lipid oxidation in wall
• Progression through stages of atherosclerosis
• Blockage/rupture of plaque
• Ischemia of blood to heart
• Death/morbidity via MI

Electro-negative LDL
Aggregated LDL
TG-rich Lipoproteins
Risk and factor models
FH mortality—implications for causality
ApoB48
Albumin
Vasa vasorum
'Atherosclerosis' in veins

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Dave Feldman

Biography:
“I’m a senior software engineer and entrepreneur.
“I began a Low Carb, High Fat diet in April 2015 and have since learned everything I could about it with special emphasis on cholesterol given my lipid numbers spiked substantially after going on the diet. As an engineer, I spotted a pattern in the lipid system that’s very similar to distributed objects in networks.
“I’ve since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data. With this new general theory, I’ve shifted around my cholesterol substantially without any drugs or special supplements of any kind.
From: https://cholesterolcode.com/about/

Blog: https://cholesterolcode.com/
Twitter: https://twitter.com/realDaveFeldman

Citizen Science Foundation:
Site: https://citizensciencefoundation.org/
Twitter: https://twitter.com/realCSF
DONATE: https://citizensciencefoundation.org/donate/

Own Your Labs: https://ownyourlabs.com/

Tucker Goodrich
Blog: http://yelling-stop.blogspot.com/
Substack: https://tuckergoodrich.substack.com/
Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg
Podcast: https://sites.libsyn.com/408758
Twitter: https://twitter.com/TuckerGoodrich

Looking to fix your diet by getting rid of seed oils?
Check out the Seedy app!
https://www.seedyapp.com/

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Show Notes
Notes
See the canine LMHR study:

Kronfeld, D. S., Hammel, E. P., Ramberg, C. F., & Dunlap, H. L. (1977). Hematological and metabolic responses to training in racing sled dogs fed diets containing medium, low, or zero carbohydrate. The American Journal of Clinical Nutrition, 30(3), 419–430. https://doi.org/10.1093/ajcn/30.3.419

Lipid-Energy Model

Norwitz, N. G., Feldman, D., Soto-Mota, A., Kalayjian, T., & Ludwig, D. S. (2022). Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype. Current Developments in Nutrition, 6(1), nzab144. https://doi.org/10.1093/cdn/nzab144

Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), Article 5. https://doi.org/10.3390/metabo12050460

PubMed for Dave's other papers:

https://pubmed.ncbi.nlm.nih.gov/?term=norwitz+feldman&sort=pubdate

See Substack for full show notes—They don't fit here

https://tuckergoodrich.substack.com/