Sceletium Tortuosum Extract for Anxiety

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/embrin (Sceletium tortuosum extract) is a standardized patented extract of Sceletium tortuosum, a South African plant that has been used for centuries for its medicinal benefits, as well as its mood-enhancing and anti-anxiety properties. Sceletium tortuosum contains active ingredients known as alkaloids that have been shown to selectively inhibit serotonin reuptake. Serotonin is a molecule (a chemical "messenger" or neurotransmitter) that plays an important role in modulating mood and other behaviors such as sleep and perception of pain. Serotonin can also suppress elevated activity in the amygdala (the region of the brain involved with emotions, emotional behavior and motivation), which has been correlated with anxiety and fear response in animal and clinical studies. Inhibiting serotonin reuptake, which keeps levels of serotonin higher, is reported to be one of the pharmacological actions by which Sceletium tortuosum can affect mood and anxiety states, as well as sleep quality. Incidentally, serotonin reuptake inhibitors are among the most widely prescribed compounds for treatment of anxiety disorders and depression. /embrin has been patented for use as a serotonin-uptake inhibitor in formulas designed to help manage anxiety and depression. In a recent randomized double-blind, placebo-controlled study, participants taking Zembrin® reported positive effects from taking the patented extract, including improvement in sleep and in handling stress. In another double-blind, placebo-controlled, cross-over study, a single dose of Zembrin® was shown to reduce anxiety-related brain activity in healthy participants.4-16

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