Prof. Hironori Nakagami @ FLOGEN SIPS 2022 Yoshikawa Intl. Symposium on Oxidative Stress

FLOGEN SIPS 2022: Yoshikawa International Symposium on Oxidative Stress for Sustainable Development of Human Beings (2nd international Symposium)

Presenter:
Prof. Hironori Nakagami, Osaka University Graduate School of Medicine, Osaka, Japan

Title:
A Prospective, Placebo-Controlled, Double-Blind Study to evaluate the impact of NMN (Nicotinamide Mononucleotide) on Diabetic Patients with Impaired Physical Performance

Abstract
Nicotinamide adenine dinucleotide (NAD+) is involved in regulating various biological processes and decreased with aging or oxidative stress [1]. Nicotinamide mononucleotide (NMN) increases intracellular NAD+ levels and counteracts age-associated changes [2,3]. We investigated the safety and efficacy of oral NMN supplementation (250 mg/day) in older diabetic patients with impaired physical performance. We conducted a 24-week placebo-controlled, double-blind study for male diabetic patients aged 65 years or older with reduced grip strength (less than 26 kg) or reduced walking speed (lenn than 1.0 m/sec). We studied 14 participants aged 81.1±6.4 years. NMN was tolerable without any related severe adverse events. The changes in grip strength and walking speed showed no difference between the two groups; However, there were trends toward an improved prevalence of frailty in the NMN group (p=0.066) and different changes in central retinal thickness between the two groups (P=0.051). In conclusion, in the present study performed on older male diabetic patients with physically impaired performance, a 24-week administration of 250 mg NMN was safe. Still, it did not affect grip strength or walking speed. However, a subanalysis indicated that NMN has the potential to improve frailty status and central retinal thickness. Directions to improve frailty and retinal thickness with NMN may be a further expected issue to be investigated.

References:

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[2] Yoshino J, Mills KF, Yoon MJ, Imai SI. Cell Metab 2011; 14: 528-536.

[3] Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Science 2021; 372: 1224-1229.