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References:

1. Schmid D, Schürch C, Blum P, Belser E, Züll F. Plant stem cell extract for longevity of skin and hair. SÖFW J. 2008;134(5):30–35. [Google Scholar]•• Connection of plant stem cells to skin and hair evidence-based literature.
Schmid et al. produced stem cells of an old rare apple plant grown in Switzerland with very good storage properties, by applying plant cell culture technique. The extract of the cultured apple stem cells was obtained after plant cells lysis using high pressure homogenization and had shown multiple beneficial applications [11].

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674215/#B11

2. Clinical trial of Malus domestica (Phytocell Tech™), a liposome encapsulated extract of cultured apple stem cells as a cosmetic ingredient has shown significant potential to reduce wrinkles in the crow's feet area of the face [11]. Depth of wrinkles was measured using the optical device, PRIMOS system for 3D skin surface display, and showed that the wrinkles became shallower by 8% after 2 weeks and shallower by 15% after 4 weeks.

https://kevaind.org/image/product/attachment/Plant%20Stem%20Cell%20Extract%20for%20Longevit290915052159.PDF

3. "Swiss apple stem cells have been shown to have anti-aging properties. They help to reduce the appearance of fine lines and wrinkles, and they can also help to improve skin texture and tone. This is because they promote the production of new skin cells and increase collagen and elastin production."

https://www.revivalabs.com/swiss-apple-stem-cells-the-revolutionary-ingredient-in-skincare/

4. Cell regulators and their effects on collagen metabolism: [1] Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110621/

5. The apple cell culture extract has undergone rigorous testing, demonstrating its ability to enhance skin stem cell vitality by an impressive 92% compared to untreated cells. Furthermore, clinical studies involving women with sun-damaged skin revealed significant improvements in skin firmness and density, with increases of 5.9% and 10.5%, respectively. Skin elasticity also saw a positive enhancement of 4.7%.

https://www.hsh-chemie.com/industry-news/industry-news-single/apple-cell-culture-extract

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