MK-677 Suppresses Testosterone Synthesis || Why Ghrelin Mimetics Shouldn’t Be Used to Bridge Cycles

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Citations:
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https://www.nature.com/articles/45230

Stevanović, D., Milošević, V., Starčević, V. P., & Severs, W. B. (2007). The effect of centrally administered ghrelin on pituitary ACTH cells and circulating ACTH and corticosterone in rats. Life sciences, 80(9), 867-872. https://www.sciencedirect.com/science/article/abs/pii/S0024320506008666

Kluge, M., Riedl, S., Uhr, M., Schmidt, D., Zhang, X., Yassouridis, A., & Steiger, A. (2010). Ghrelin affects the hypothalamus–pituitary–thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma. European journal of endocrinology, 162(6), 1059-1065. https://eje.bioscientifica.com/view/journals/eje/162/6/1059.xml

Lanfranco, F., Motta, G., Baldi, M., Gasco, V., Grottoli, S., Benso, A., ... & Ghigo, E. (2010). Ghrelin and anterior pituitary function. Pituitary Today II, 38, 206-211.https://www.karger.com/Article/Abstract/318512

Fernández-Fernández, R., Tena-Sempere, M., Aguilar, E., & Pinilla, L. (2004). Ghrelin effects on gonadotropin secretion in male and female rats. Neuroscience letters, 362(2), 103-107. https://www.sciencedirect.com/science/article/abs/pii/S0304394004002733

Kluge, M., Schussler, P., Uhr, M., Yassouridis, A., & Steiger, A. (2007). Ghrelin suppresses secretion of luteinizing hormone in humans. The Journal of Clinical Endocrinology & Metabolism, 92(8), 3202-3205. https://academic.oup.com/jcem/article-abstract/92/8/3202/2598294

Lanfranco, F., Bonelli, L., Baldi, M., Me, E., Broglio, F., & Ghigo, E. (2008). Acylated ghrelin inhibits spontaneous LH pulsatility and responsiveness to naloxone, but not that to GnRH in young men: evidence for a central inhibitory action of ghrelin on the gonadal axis. J Clin Endocrinol Metab, 93, 3633-3639. https://d1wqtxts1xzle7.cloudfront.net/44866300/Acylated_ghrelin_inhibits_spontaneous_lu20160418-22105-165wxa0.pdf?1461015400=&response-content-disposition=inline%3B+filename%3DAcylated_Ghrelin_Inhibits_Spontaneous_Lu.pdf&Expires=1624904317&Signature=EMv8u7id7KGqmfRy2PGCZBqKc7U2B628qwa~~A8coCV~iRVewAeQVKOKHzhXMf~HFn6pIYyC8TOlwTkKStbak96Sopol~YrTvdnaeLRGnQQ0j2TqjFZHdR4UCFLoBdSuokmWnLmCRpc4-jXZnyV6~uvkGG2iPQnJOY5jnbH6MTM8RDvl4mQ24GoK6xGW6N5MZuWqcdizgZnWjJxghJE0vg7BgBEBfdlRtM4liNoNJsJvAJ61e1lZ0LRoWzsj0D5kiM9x4p4RmkILICoDz8wtIHCx0GueZyJGi2dSS1XwDAXO9AZyyABGOHoL4gzWXnu61v-fas1K2cl00kBzqRwq4A__&Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA

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Poretti, M. B., Frautschi, C., Luque, E., Bianconi, S., Martini, A. C., Stutz, G., ... & Carlini, V. P. (2018). Reproductive performance of male mice after hypothalamic ghrelin administration. Reproduction, 156(2), 121-132.https://rep.bioscientifica.com/view/journals/rep/156/2/REP-17-0535.xml

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