This is How GH Calms the Nerves

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Citations:
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Rosen, T., & Bengtsson, B. Å. (1990). Premature mortality due to cardiovascular disease in hypopituitarism. The Lancet, 336(8710), 285-288. https://www.sciencedirect.com/science/article/abs/pii/014067369091812O

Sverrisdóttir, Y. B., Elam, M., Herlitz, H., Bengtsson, B. A., & Johannsson, G. (1998). Intense sympathetic nerve activity in adults with hypopituitarism and untreated growth hormone deficiency. The Journal of Clinical Endocrinology & Metabolism, 83(6), 1881-1885.
https://academic.oup.com/jcem/article/83/6/1881/2865190?login=true

Leong, K. S., Mann, P., Wallymahmed, M., MacFarlane, I. A., & Wilding, J. P. (2000). Abnormal heart rate variability in adults with growth hormone deficiency. The Journal of Clinical Endocrinology & Metabolism, 85(2), 628-633. https://academic.oup.com/jcem/article/85/2/628/2853787?login=true

Cohn, J. N., Levine, T. B., Olivari, M. T., Garberg, V., Lura, D., Francis, G. S., ... & Rector, T. (1984). Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. New England journal of medicine, 311(13), 819-823. https://www.nejm.org/doi/full/10.1056/nejm198409273111303

Kaye, D. M., Lambert, G. W., Lefkovits, J., Morris, M., Jennings, G., & Esler, M. D. (1994). Neurochemical evidence of cardiac sympathetic activation and increased central nervous system norepinephrine turnover in severe congestive heart failure. Journal of the American College of Cardiology, 23(3), 570-578. https://www.jacc.org/doi/abs/10.1016/0735-1097(94)90738-2

Capaldo, B., Lembo, G., Rendina, V., Vigorito, C., Guida, R., Cuocolo, A., ... & Saccà, L. (1998). Sympathetic deactivation by growth hormone treatment in patients with dilated cardiomyopathy. European heart journal, 19(4), 623-627. https://academic.oup.com/eurheartj/article/19/4/623/480474?login=true

Andersson, I. J., Barlind, A., Nyström, H. C., Olsson, B., Skøtt, O., Mobini, R., ... & Bergström, G. (2004). Reduced sympathetic responsiveness as well as plasma and tissue noradrenaline concentration in growth hormone transgenic mice. Acta physiologica scandinavica, 182(4), 369-378. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-201X.2004.01368.x

Balldin, J., Berggren, U., Eriksson, E., Lindstedt, G., & Sundkler, A. (1993). Guanfacine as an alpha-2-agonist inducer of growth hormone secretion—a comparison with clonidine. Psychoneuroendocrinology, 18(1), 45-55. https://www.sciencedirect.com/science/article/abs/pii/030645309390054O

Mundinger, T. O., Cummings, D. E., & Taborsky Jr, G. J. (2006). Direct stimulation of ghrelin secretion by sympathetic nerves. Endocrinology, 147(6), 2893-2901.
https://academic.oup.com/endo/article-abstract/147/6/2893/2879507

Zhao, T. J., Sakata, I., Li, R. L., Liang, G., Richardson, J. A., Brown, M. S., ... & Zigman, J. M. (2010). Ghrelin secretion stimulated by β1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proceedings of the National Academy of Sciences, 107(36), 15868-15873. https://www.pnas.org/content/107/36/15868.short

#anxiety #gh