Neurosteroids and Endocannabinoids Govern Your Anxiety

Continuing our series with a discussion of the natural ligands of the GABA-A receptors.

TIMESTAMPS:
00:00 Introduction
00:41 Endogenous modulators of GABA-A
01:08 Allosteric vs. orthosteric binding sites
02:08 Neurosteroids
02:18 Post-finasteride syndrome
02:35 Sites of steroidogenesis
03:00 The TSPO receptor
03:45 Allopregnanolone
03:49 THDOC
04:25 Post-partum depression
05:15 Build-in modulators
06:04 Sulfated DHEA and pregnenolone: antagonists
06:35 High concentrations - direct agonism
07:20 2-Arachidonoylglycerol
07:40 Summary

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