Chemotherapy: The Hidden Risks You Should Know About

Chemotherapy can stop cancer cells from replicating, but it comes with a cost many don’t realize: it accelerates aging in the body, which is one of the root causes of cancer itself.

Here’s a quick breakdown of what happens when chemotherapy-induced senescence takes place:

1 Alters the Tumor Environment: Chemotherapy increases what’s called Senescence-Associated Secretory Phenotype (SASP), which releases growth factors and cytokines that make the tumor’s microenvironment more favorable for cancer progression.

2 Harder to Treat: It promotes tumor heterogeneity—meaning different cancer cell types emerge within the tumor, making it tougher to treat and more likely to resist therapies.

3 Resistance Grows: Chemo leads to resistance, especially in cancer stem cells, creating therapy-resistant clones that continue to thrive despite treatment.

4 Cancer Adapts: Over time, cancer cells adapt to chemotherapy, developing lifelong resistance, making it harder to treat in the future.

At Williams Cancer Institute, we avoid these harmful effects by using Intratumoral Therapy, a more advanced and targeted approach that eliminates cancer cells without promoting aging or resistance. This therapy offers patients a powerful alternative to conventional treatments that can do more harm than good.

Take control of your health and explore the benefits of a more personalized, less invasive approach to cancer treatment.

Supporting Evidence:

Guillon J, Petit C, Toutain B, Guette C, Lelièvre E, Coqueret O. Chemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneity. Cell Cycle. 2019 Oct;18(19):2385-2397. doi: 10.1080/15384101.2019.1652047.

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