What can cause someone to lose their Humanity?

The fear of losing one's humanity is a common plot thread in stories, yet is it also possible for it to happen in real life?

In this video, Jonah shares his thoughts on this topic.

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And the link to Jonah's first book; Mykal Orion and the Station of Thieves:
https://www.amazon.com/Mykal-Orion-Station-Thieves-interesting-ebook/dp/B06Y2LGSY