Does Size Matter When It Comes To Mesenchymal Stem Cells?

Does Size Matter? The Truth About Mesenchymal Stem Cells 🧬✨

At Dream Body Clinic, we’re often asked if the size of mesenchymal stem cells (MSCs) truly affects their effectiveness, especially for neurodegenerative conditions. Here, we break down this common question and dive into the science behind MSC treatments.

Understanding Stem Cell Size and the Blood-Brain Barrier 🧠🔬

Some sources claim smaller MSCs are more effective at crossing the blood-brain barrier to aid in neurological recovery. However, this isn’t accurate—our head biologist explains that the blood-brain barrier’s permeability is measured in Daltons, not microns (the unit of cell size). Whether MSCs are 10 or 20 microns doesn't impact their ability to reach the brain, as the blood-brain barrier operates differently from simple size-based filters.

Intravenous vs. Intrathecal Delivery Methods 💉

For patients seeking optimal brain-related benefits, we recommend intrathecal (spinal) injections rather than intravenous (IV) administration. IV MSCs go through the body’s filter organs—lungs, liver, kidneys—before potentially reaching the brain, whereas intrathecal delivery allows MSCs to travel directly within cerebrospinal fluid, enhancing their access to the brain.

The Real Power of MSCs: Exosomes and Growth Factors 🌱

MSCs work through the release of exosomes, which contain growth factors like VEGF, BDNF, and NGF. These molecules can support nerve regeneration and inhibit cell death, providing critical neuroprotection. Regardless of MSC size, it’s these growth factors and exosomes that carry out the vital work of healing and regeneration.

Why Source Matters More Than Size 🌿👶

At Dream Body Clinic, we source MSCs from Wharton’s jelly found in umbilical cords—an ideal choice as they are young and vigorous, which leads to the most effective replication and treatment outcomes. Sourcing is what truly matters for delivering optimal cell health and replication capacity.

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