7 Repurposed Medications to Augment Chemotherapy

Interested in how existing medications can play a new role in cancer treatment?

Here’s a look at some repurposed drugs that are gaining attention for enhancing radiation therapy effectiveness.

1. Metformin • 🔍 Mechanism: Activates AMPK and inhibits mTOR, decreasing tumor proliferation and increasing sensitivity to radiation. ⚡ • Reference: Pollak M., Cancer Prev Res (Phila), 2010.

2. Aspirin (Acetylsalicylic Acid) • 🔍 Mechanism: COX-2 inhibition reduces inflammation and tumor hypoxia, boosting radiosensitivity. 🌿 • Reference: Thun MJ et al., Nat Rev Clin Oncol, 2012.

3. Propranolol • 🔍 Mechanism: Reduces adrenergic signaling, improving blood flow and reducing tumor survival. Enhances radiation response. 💊 • Reference: Wang HM et al., Cancer, 2013.

4. Statins (e.g., Simvastatin) • 🔍 Mechanism: Impairs lipid rafts and crucial signaling pathways, sensitizing cancer cells to radiation. 🛑 • Reference: Demierre MF et al., Nat Rev Cancer, 2005.

5. Disulfiram • 🔍 Mechanism: Increases ROS, leading to oxidative stress and apoptosis—greatly enhancing radiation damage. 💥 • Reference: Cen D et al., J Med Chem, 2004.

6. Chloroquine • 🔍 Mechanism: Inhibits autophagy, enhancing the effectiveness of radiation-induced cancer cell death. 🧬 • Reference: Amaravadi RK et al., Genes Dev, 2016.

7. Valproic Acid • 🔍 Mechanism: HDAC inhibition increases radiation-induced DNA damage, enhancing cancer cell death. ⚔️ • Reference: Munshi A et al., Int J Oncol, 2001.

Go to the link in my bio to access more resources and dive deeper into how these therapies might change the game in oncology.

Supporting Evidence in the caption below ⬇️⬇️

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