Destroy All Humans! 2 (2006) - Ep. 1 | PCSX2 1.7 Nightly

EE Cycle Rate - 180%
Renderer - Direct3D 12
Aspect Ratio - 16:9
FMV - 16:9
Internal Resolution 4x Native (2K)
Mippmapping - Full (PS2)
Anisotropic Filtering - 16x
Dithering - Scaled
Blending Accuracy - Full
Texture Preloading - Full
Filters - Wave Filter (Looks better overall and it's simple)
■ - Shade Boost
Shade Boost Brightness - 50
Shade Contrast - 50
Shade Saturation - 60
[Optional] Enable Achievements! (Not all games will have them)