Rational design anticancer cannabinoids. #DrugDesign.

Taking with quaternary ammonium bases has several advantages in the development of cannabinoids. Firstly, such substances do not pass the blood-brain barrier and do not have a narcotic effect, which is critically important for ease of use and mass use. Secondly, both CB2 and CB1 active substances have anticancer properties, as well as GPR-55 in some cases. It is obvious that selective drugs may be less versatile and possibly less active, and complex quaternary ammonium bases may be the most convenient and effective solution for the pharmacological market. It is also worth noting that quaternary ammonium bases may have anticancer potential as ion blockers on the surface of biological membranes. They can also be active as apoptosisinducing agents, with anticancer radicals close to terpenes and phenols, this can enhance the anticancer effect. Also, a feature of the presented design is a wide range of physicochemical and pharmacological properties: Surface active properties - such substances can accumulate in the lungs when administered by inhalation. Also, substances can accumulate in the gastrointestinal tract, because such substances do not pass biological membranes relatively quickly. It is an excellent prospect for use in cases of skin, gastrointestinal or lung cancer. Also, these substances are well soluble in water and can be used by injection, intravenous .. including injections into the focus and metastases. .. .. .. ..