Access Into The BRAIN " DAVOS 2025

Access Into The BRAIN " DAVOS 2025 - Did you know? In 2019, DARPA (the Defense Advanced Research Projects Agency) granted Battelle's neuro team the contract for injectable brain control technology.

Additional info:
The blood–brain barrier is a physiological barrier that can prevent both small and complex drugs from reaching the brain to exert a pharmacological effect. For treatment of neurological diseases, drug concentrations at the target site are a fundamental parameter for therapeutic effect; thus, the blood–brain barrier is a major obstacle to overcome. Novel strategies have been developed to circumvent the blood–brain barrier, including CSF delivery, intracranial delivery, ultrasound-based methods, membrane transporters, receptor-mediated transcytosis, and nanotherapeutics. These approaches each have their advantages and disadvantages. CSF delivery and intracranial delivery are direct but invasive techniques that have not yet shown efficacy in clinical trials, although development of novel delivery devices might improve these approaches. Ultrasound-based disruption has shown some efficacy in clinical trials, but it can require invasive procedures. Approaches using membrane transporters and receptor-mediated transcytosis are less invasive than are other techniques, but they can have off-target effects. Nanotherapeutics have shown promise, but these strategies are in early stages of development. Advancements in drug delivery across the blood–brain barrier will require appropriately designed and powered clinical studies, with a focus on the timing of treatment, demographic and genetic considerations, head-to-head comparison with other treatment strategies (rather than a placebo), and relevant primary and secondary outcome measures.
The three-phase program is called Next-Generation Nonsurgical Neurotechnology (N3) & aims to develop bi-directional brain control technology interfaces called BrainSTORMS (Brain System to Transmit Or Receive Magnetoelectric Signals). It employs magnetoelectric nanotransducers (MEnTs) localized in neural tissue for brain–computer interface applications. One of the key MEnT attributes are their incredibly small size in that thousands of MEnTs can fit across the width of a human hair. The MEnTs are first injected into the circulatory system and then guided with a magnet to the targeted area of the brain.

Reference: the lancet neurology https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00476-9/abstract

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