How does IVERMECTIN work..? | Ward Dean MD

Dive deep into the science behind Ivermectin, an antiparasitic drug renowned for its effectiveness against a range of parasites.

In this video, we cover:

What is Ivermectin? - A brief introduction to Ivermectin, detailing its origins, uses, and why it's considered significant in both veterinary and human medicine.

Mechanism of Action:

Parasite Paralysis: Ivermectin primarily works by binding to glutamate-gated chloride channels in the nerve and muscle cells of parasites. This binding increases the permeability of the cell membrane to chloride ions, leading to hyperpolarization, paralysis, and ultimately death of the parasite.

Gamma-Aminobutyric Acid (GABA) Agonist: Additionally, Ivermectin acts as an agonist for the neurotransmitter GABA, further disrupting nerve impulse transmission within the parasite, which does not affect mammals in the same way due to the protective blood-brain barrier.

Applications in Medicine:

Human Treatments: We discuss its FDA-approved uses for treating conditions like onchocerciasis ("river blindness"), strongyloidiasis, head lice, and scabies.

Veterinary Uses: Highlighting its role in animal health for treating heartworms, mange, and other parasitic infections.

Pharmacokinetics:
Absorption and Distribution: How Ivermectin is absorbed into the body, its distribution, and why it doesn't easily cross the blood-brain barrier in mammals.

Metabolism and Excretion: The process of how Ivermectin is metabolized in the liver and excreted from the body.

Safety and Side Effects:

In Humans: We'll touch on common side effects, precautions, and why it's important to use the drug at prescribed doses.

Controversies and Current Research:
A brief discussion on the controversy surrounding Ivermectin, including its off-label use and the importance of evidence-based medicine in evaluating new applications.

Conclusion: Summarizing why Ivermectin is vital in the fight against parasitic diseases, the science behind its effectiveness, and the necessity for its proper administration.

Call to Action:
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This description aims to provide viewers with a comprehensive yet engaging explanation of Ivermectin’s functionality, highlighting its scientific principles, applications, and the importance of responsible use.