Slowing Down Aging: The Power of Vitamin D, Omega-3, and Exercise EP. 1231 MAR 2025

This research, a component of the larger DO-HEALTH trial, specifically examined the impact of vitamin D, omega-3 fatty acids, and exercise on DNA methylation clocks, indicators of biological aging, in a subset of approximately 777 older adults. While the broader DO-HEALTH trial included over 2,000 participants, this particular study focused on those with available DNA methylation data. The researchers found that a combined intervention of vitamin D, omega-3, and exercise led to a noticeable slowing of biological aging, as reflected in the DunedinPACE epigenetic clock. Although individual interventions also showed some positive trends, the combined approach demonstrated the most significant effect. This study highlights how targeted lifestyle interventions can potentially influence biological aging in older adults, based on analysis of a specific subset of the DO-HEALTH trial participants.
Disclaimers:

"This information is for educational purposes only and should not be interpreted as medical advice."
"The study discussed was conducted on a subset of older adults from the DO-HEALTH trial. Further research may be needed to confirm these findings in other populations."
"Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or exercise program, especially if you have a medical condition or are taking medications."
"This channel does not provide medical advice."

#BiologicalAging #VitaminD #Omega3 #Exercise #DNAMethylation
Bischoff-Ferrari, H.A., Gängler, S., Wieczorek, M. et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nat Aging (2025). https://doi.org/10.1038/s43587-024-00793-y

Biological aging, DNA methylation, vitamin D, omega-3 fatty acids, exercise, older adults, DO-HEALTH trial, aging reversal, epigenetic clock, lifestyle interventions, healthy aging, cellular aging, gerontology, longevity, aging biomarkers, clinical trial, nutritional supplements, physical activity, epigenetic modifications, methylation patterns, aging research, preventative medicine, geriatrics, anti-aging strategies, molecular biology, healthspan.