New trillion dollar drug

If the pharmaceutical industry,

(Dr Michael Holick)

had developed a single drug capable of:

Reducing cancer mortality by more than 25%

Reducing the incidence of metastatic and fatal cancer by 38%

Reducing autoimmune disorders by 39%

Reducing type 1 diabetes by 88%

Preventing advancement of prediabetes to type 2 diabetes by 76%

Reducing peripheral vascular disease by 80%

Lowering risk of upper respiratory tract infections by 58%

Reducing covid infectivity by 54%

Reducing COVID 19 infection by up to 74%

Reducing covid RDS by 78%

Reducing COVID 19 hospitalizations by up to 22%

Reducing COVID 19 mortality by up to 45 – 66%

Accelerating COVID positive patients to COVID negativity by 66%

Reducing risk of preterm birth by 62%

Reducing risk of pre-eclampsia by more than 50%

Reducing gestational diabetes, 50%

Reducing infant dental caries, 75%

Reducing multiple sclerosis, 62%

Colon cancer, 80%

Cardiovascular mortality, 67%

Autoimmune disease, 39%

the drug would be heralded as a “miracle drug.”

With patent protection, this single drug sold worldwide would be the first trillion-dollar drug.

The sunshine vitamin D provides all these health benefits especially when an adequate amount is taken to sustain circulating concentrations of 25(OH)D of at least 30 ng/ mL, (75 nm / L)

with the maximum benefit obtained with concentrations of 40- 60 ng/mL,(100 – 150 nm / L)

At least 30 ng/ mL

Best, 40- 60 ng/mL.

GDP (Guideline Development Panel, US Endocrine Society)

24% or more (children and adults),
United States, have a circulating concentration of 25(OH)D less than 20 ng/mL.

Approximately 40% in Europe have a circulating concentration of 25(OH)D less than 20 ng/mL.

Recent report from the VITAL trail

https://www.bmj.com/content/376/bmj-2021-066452

For the last 3 years of the intervention

Group receiving 2000 IUs vitamin D3 daily raised their serum concentration of 25(OH)D from 29.8 ng/mL to 41.8 ng/mL after 1 year

This group had 39% fewer confirmed autoimmune diseases than the placebo group (who were permitted to take up to 800 IUs daily)

NIH, 5 – 8% in US have an autoimmune condition.

When should I suspect or test for vitamin D deficiency?

https://cks.nice.org.uk/topics/vitamin-d-deficiency-in-adults/diagnosis/diagnosis/

Do not routinely test for vitamin D deficiency in people who are asymptomatic.