More vaccine gives more infections

Bottom line of this video, Flu jab, calculated vaccine effectiveness of −26.9%

N = 43,857

‘This study found a significantly higher risk of influenza among the vaccinated,

compared to the unvaccinated state in northern Ohio during the 2024-2025 influenza season.’

Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine (April 2023, Cleveland Clinic)

https://academic.oup.com/ofid/article/10/6/ofad209/7131292?login=false

‘The higher the number of vaccines previously received, the higher the risk of contracting COVID-19’

Effectiveness of the Influenza Vaccine During the 2024-2025 Respiratory Viral Season

https://www.medrxiv.org/content/10.1101/2025.01.30.25321421v3

Study to evaluate effectiveness of influenza vaccine during the 2024-2025 respiratory viral season.

Methods

Employees of Cleveland Clinic in employment in Ohio on October 1, 2024, were included.

The cumulative incidence of influenza,

Vaccinated status

Unvaccinated status

Compared over the following 25 weeks.

Results

Among 53,402 employees, 43,857 (82.1%) had received the influenza vaccine by the end of the study.

Influenza occurred in 1,079 (2.02%) during the study.

The cumulative incidence of influenza was similar for the vaccinated and unvaccinated states early,

but over the course of the study the cumulative incidence of influenza increased more rapidly among the vaccinated than the unvaccinated.

In an analysis adjusted for age, sex, clinical nursing job, and employment location, the risk of influenza was significantly higher for the vaccinated compared to the unvaccinated state, HR, 1.27

95% C.I., 1.07 – 1.51

P = 0.007

Yielding a calculated vaccine effectiveness of −26.9%

95% C.I., −55.0 to −6.6%

The results are generalizable to relatively healthy adults in the USA,

which is a major target of adult influenza vaccination efforts.

Although the study was done in northern Ohio,

there is little reason to assume that the effectiveness of the vaccine would have been different in a different geographic region within the continental USA.

Conclusions

This study found that influenza vaccination of working-aged adults was associated with a higher risk of influenza during the 2024-2025 respiratory viral season,

suggesting that the vaccine has not been effective in preventing influenza this season.

Some details

Influenza, respiratory viral infection, 145 000 deaths worldwide among all ages in 2017

1918, case fatality rate 2.5%, more than 50 million deaths worldwide

Seasonal pattern to illness

Annual influenza vaccination is often recommended

Trivalent inactivated vaccine (TIV), two influenza A virus types (H3N2 and H1N1),

and an influenza B virus type

Efficacy will vary depending on prognostication

mRNA pressure?