Bergamot for Cholesterol: How It Works & Is It Safe? Ep. 1245 JUN 2025

This video explores the significant potential of bergamot, particularly its Bergamot Polyphenolic Fraction (BPF), in managing cholesterol levels, based on a review in Nutrients. Bergamot primarily lowers cholesterol by inhibiting HMG-CoA reductase, the same enzyme targeted by statins, with compounds like brutieridin and melitidin playing a key role ; in vitro studies have shown up to a 30-40% reduction in cholesterol synthesis in liver cells. Clinical trials demonstrate notable LDL-C reductions, for example, 500 mg/day of BPF decreased LDL-C by 24.1% in 30 days , while 1000 mg/day lowered LDL-C by 40.8%. Doses up to 1300 mg/day have resulted in LDL-C reductions of 37.7% over 120 days in patients with metabolic syndrome.
Regarding safety, bergamot has generally been well-tolerated in human trials lasting up to 120 days, with no significant adverse effects reported. Animal studies also indicate a good safety profile, with doses up to 150 mg/kg/day of BPF showing no liver, kidney, or blood toxicity. Even in statin-intolerant patients, 1500 mg/day of bergamot extract showed favorable results without adverse effects in one study. However, it's important to note that data on long-term safety and use at higher doses are still limited. Caution is advised for individuals on multiple medications due to the potential for drug-nutraceutical interactions, which are not yet fully understood.
Disclaimers:

"This information is for educational purposes only and should not be interpreted as medical advice."
"The review discusses findings from preclinical studies and clinical trials. While short-term human studies (up to 120 days) suggest bergamot is generally well-tolerated , comprehensive long-term safety data, especially at higher doses, is still emerging. The effects of bergamot can vary based on the individual, the formulation, and dosage."

"Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, particularly if you have a medical condition, are taking medications (especially for cholesterol or other cardiovascular issues), or are considering bergamot supplementation. Discuss potential interactions if you are on polypharmacy."
"This channel does not provide medical advice."
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Carpenito M, Coletti F, Muscoli S, Guarino L, Di Cristo A, Cammalleri V, Mega S, Emerenziani S, Cicala M, Fanali C, et al. Unveiling the Power of Bergamot: Beyond Lipid-Lowering Effects. Nutrients. 2025; 17(11):1871. https://doi.org/10.3390/nu17111871
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