Crispr: Unlocking Age Reversal and Redefining Longevity

https://www.ihadnoclue.com/article/1086082524761030657

Recent research has identified cellular senescence—where cells stop dividing but remain metabolically active—as a major contributor to aging and age-related diseases. These senescent cells accumulate in tissues over time, releasing inflammatory factors that cause tissue degeneration. Scientists have discovered that senescent cells display distinct epigenetic signatures that form part of the "epigenetic clock," one of the most accurate biomarkers of aging to date. Other aging mechanisms include telomere shortening, mitochondrial dysfunction, and declining protein quality control. Researchers are now using CRISPR-Cas9 gene editing technology to combat cellular aging through various approaches: reprogramming senescent cells rather than eliminating them, creating genetic maps of senescence triggers, controlling the timing of gene editing, and enhancing natural repair mechanisms. This research is rapidly moving from labs to clinical applications, with companies like Rejuvenate Bio and Altos Labs conducting trials and attracting significant investment. While these technologies hold enormous promise for extending "healthspan," they also raise profound ethical questions about lifespan extension, resource allocation, and treatment access.