Week 53 - When a Dose is Done

This episode explores how to recognize when a GLP-1 medication dose—such as Mounjaro—may be losing effectiveness and what signs to monitor. From changes in heart rate variability to the return of old habits like food cravings and digestive shifts, this is a deep dive into understanding dose fatigue and planning next steps.

💉 Topics covered:

How to tell when a GLP-1 dose is no longer working

Receptor desensitization and why medication effects diminish over time

Heart rate and heart rate variability (HRV) patterns during each dose cycle

The relationship between cravings, digestion, and ADHD symptoms

Tracking wellness using Apple Watch, HealthKit, and other tools

What to consider before increasing to the next GLP-1 dose

Strategy and timing when approaching the highest dose options

Natural methods to support GLP-1 sensitivity after stopping medication

🧠 Emotional eating triggers—such as stress, boredom, or social dynamics—are also discussed, along with ideas for how to build new habits that don't rely on medication.

📈 Heart rate variability (HRV) is highlighted as an emerging metric for overall health, energy levels, and stress management. Learn how to track and interpret HRV patterns through wearable devices and fitness apps.