Galectin-9 Bridges B Cells to Endothelium | Deep Dive into Glycobiology & Immunoregulation

In this episode, we break down one of my favorite biomedical research papers:
“Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways” (Chakraborty et al., Journal of Autoimmunity, 2021).

We’ll explore how Galectin-9 functions as both an adhesion molecule and an immune modulator, its interaction with B cell surface glycans like CD45, and its impact on SLAMF7 and ERK signaling pathways.

This paper highlights the critical but often overlooked role of glycobiology in immune cell dynamics—and why more scientists (and platforms!) need to pay attention to it.

A huge shoutout to the Dimitroff Lab for their continued work at the frontiers of translational glycobiology, and special recognition to Dr. Asmi Chakraborty for leading such an elegant and impactful study.

🧬 Topics Covered:
Galectin-9 structure and function
B-cell adhesion and TEM inhibition
Endothelial cell signaling
Glycans, CD45, and SLAMF7 regulation
The silent power of glycosylation in immunity

#Glycobiology #Galectin-9 #Gal-9 #galectins #bcells #immunology #biomedicalscience #ScientificPodcast #GlycanScience #CellAdhesion #EndothelialCells #sciencecommunication #DimitroffLab
#biotechnology

Chakraborty, Asmi, et al. "Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways." Journal of autoimmunity 117 (2021): 102575.