The Four Hormones Most Adults Need More of - Interview with Georgi Dinkov

In this interview, biohacker and repeat guest Georgi Dinkov and I discuss the four hormones most adults need more of they want to optimize their health. In my introduction I mention that we will review the benefits and mechanisms of action of carbon dioxide (CO2), but that will be covered in Part 2 of this interview.

Four hormones most adults can benefit from are progesterone, thyroid hormone T3, DHEA and pregnenolone.

Around the ages of 11 and 12, right before puberty, the hormonal profiles of boys and girls are relatively similar. They produce about the same amounts of pregnenolone and progesterone. This is also the time when thyroid hormone levels are the highest they’ll ever be, and it’s the time in a person’s life cycle when their mortality is the lowest. Most supplementation recommendations are based on these prepubescent levels.

To optimize bioavailability, take T3, DHEA and/or pregnenolone orally, after dissolving them in a long-chain fat (14 carbons or more) such as ghee or moringa oil.

The normal daily output of DHEA by the adrenal gland is about 20 to 50 milligrams (mg), so for most people, the max DHEA dose would be 50 mg, ideally split into several smaller doses. Human studies have shown that once you take more than 50 mg of DHEA per day, you begin to increase estrogen biomarkers.

As a general recommendation, I recommend taking 30 to 50 mg of bioidentical progesterone per a day, taken in the evening before bed, as it can promote sleep. The same dose (30 to 50 mg a day) is recommended for pregnenolone. This is the physiological dose, meaning it’s what you need for full replenishment, assuming you're producing nothing.

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