Left on the doorstep of an orphanage run by nuns, three newborn knuckleheads grow up to be finger-poking, nyuk-nyuking janitors named Larry (Sean Hayes), Curly (Will Sasso) and Moe (Chris Diamantopoulos). When they learn that financial problems will soon force the only home they've ever known to close, the trio sets out to raise $830,000 in one month. Out in the world for the very first time, the three innocent bumblers become embroiled in a murder plot and find stardom on a TV reality show.

Moe, Larry and Curly-Joe find themselves in a hilarious showdown against alien spies as they strive to protect a quirky scientist's groundbreaking new vehicle.

In a distant kingdom a great king has died, leaving his daughter, Snow White (Carol Heiss), vulnerable to the whims of his successor, the Evil Queen (Patricia Medina). To secure her crown, the queen orders her squire to murder the young princess. But the evil scheme fails, and Snow White escapes into the forest. There she encounters a cottage occupied by three lunkheaded puppeteers (The Three Stooges) and their charge, Quatro (Edson Stroll), a young man hiding his true identity.

Eyes will be poked, noses pulled, faces slapped, heads bonked -- the usual sort of slapstick awaits the viewer in this collection of Three Stooges shorts strung together as a feature film involving a ventriloquist giving a history lesson to his dummy. Here Moe, Larry and Curly appear in a variety of guises: the Stooges as cowboys, the Stooges as tramps, the Stooges as dog-groomers, the Stooges as plumbers, the Stooges as professors, and so on, with each adventure aiming for maximum yuks.

On the grounds of the National Space Foundation, maintenance workers Moe (Moe Howard), Larry (Larry Fine) and Curly Joe (Joe DeRita) help director J.P. Morse (Jerome Cowan) and scientists Ingrid Naarveg (Anna Lisa) and Ted Benson (Robert Colbert) when their rocket fails to launch. In the laboratory, Larry accidentally develops fuel for the rocket and, along with the monkey intended for the original trial, the three men launch themselves to Mars, where a series of creatures and adventures await.