muscle loss & the effects of senescent cells

Muscle Preservation and Senescent Cells – Maintaining muscle mass as we age is vital for strength, mobility, and longevity. Research shows that the accumulation of senescent cells—damaged or “zombie” cells that no longer divide—plays a major role in muscle loss, weakness, and impaired regeneration. These cells secrete inflammatory compounds that disrupt muscle repair, accelerate aging, and contribute to sarcopenia (age-related muscle decline). By targeting senescent cells and promoting cellular renewal, it’s possible to preserve lean muscle, improve recovery, and enhance metabolic health. Lifestyle strategies such as resistance training, optimal protein intake, fasting, and emerging senolytic therapies are being studied for their ability to clear senescent cells and support long-term muscle health. Understanding the link between muscle preservation, aging, and cellular senescence provides new insights into maintaining vitality, preventing frailty, and extending healthy lifespan.